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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RET
All Species:
9.39
Human Site:
S1104
Identified Species:
18.79
UniProt:
P07949
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P07949
NP_065681.1
1114
124319
S1104
A
N
W
M
L
S
P
S
A
A
K
L
M
D
T
Chimpanzee
Pan troglodytes
XP_001171246
813
90715
Q804
C
L
P
R
H
P
A
Q
L
A
N
G
G
L
K
Rhesus Macaque
Macaca mulatta
XP_001090823
731
81824
Q722
C
L
P
R
H
P
A
Q
L
A
N
G
G
L
K
Dog
Lupus familis
XP_543915
1108
124018
S1098
A
N
W
M
V
S
P
S
A
A
Q
L
M
D
A
Cat
Felis silvestris
Mouse
Mus musculus
P35546
1115
123855
S1105
A
N
W
M
V
S
P
S
A
A
K
L
M
D
T
Rat
Rattus norvegicus
Q04589
822
91806
Q813
C
L
P
R
H
P
T
Q
L
A
N
G
G
L
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507715
665
75620
A656
N
W
M
V
S
P
S
A
A
K
F
M
D
K
F
Chicken
Gallus gallus
P18461
823
92281
Y814
Y
E
P
C
L
P
K
Y
Q
H
M
N
G
S
V
Frog
Xenopus laevis
Q03364
813
91322
F804
H
D
P
C
L
P
K
F
Q
H
V
N
G
V
V
Zebra Danio
Brachydanio rerio
Q8JG38
817
91370
Y808
D
E
P
C
L
P
K
Y
Q
H
I
N
G
G
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q09147
1052
117795
L1043
T
F
R
E
T
S
P
L
R
Y
Q
Y
T
Y
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Q26614
972
110463
Q963
Q
V
Y
Y
K
V
P
Q
T
R
D
C
C
P
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
28.4
27.9
86.4
N.A.
83.4
28.9
N.A.
43
27.5
28.1
27.7
N.A.
23.6
N.A.
N.A.
24
Protein Similarity:
100
42.2
41.5
92
N.A.
90.2
43
N.A.
50.5
43.5
42.3
42
N.A.
37.7
N.A.
N.A.
41.2
P-Site Identity:
100
6.6
6.6
80
N.A.
93.3
6.6
N.A.
6.6
6.6
6.6
6.6
N.A.
13.3
N.A.
N.A.
6.6
P-Site Similarity:
100
6.6
6.6
93.3
N.A.
100
6.6
N.A.
26.6
6.6
13.3
6.6
N.A.
20
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
25
0
0
0
0
0
17
9
34
50
0
0
0
0
9
% A
% Cys:
25
0
0
25
0
0
0
0
0
0
0
9
9
0
0
% C
% Asp:
9
9
0
0
0
0
0
0
0
0
9
0
9
25
0
% D
% Glu:
0
17
0
9
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
9
0
0
0
0
0
9
0
0
9
0
0
0
9
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
25
50
9
0
% G
% His:
9
0
0
0
25
0
0
0
0
25
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
9
% I
% Lys:
0
0
0
0
9
0
25
0
0
9
17
0
0
9
25
% K
% Leu:
0
25
0
0
34
0
0
9
25
0
0
25
0
25
0
% L
% Met:
0
0
9
25
0
0
0
0
0
0
9
9
25
0
0
% M
% Asn:
9
25
0
0
0
0
0
0
0
0
25
25
0
0
9
% N
% Pro:
0
0
50
0
0
59
42
0
0
0
0
0
0
9
0
% P
% Gln:
9
0
0
0
0
0
0
34
25
0
17
0
0
0
0
% Q
% Arg:
0
0
9
25
0
0
0
0
9
9
0
0
0
0
0
% R
% Ser:
0
0
0
0
9
34
9
25
0
0
0
0
0
9
0
% S
% Thr:
9
0
0
0
9
0
9
0
9
0
0
0
9
0
17
% T
% Val:
0
9
0
9
17
9
0
0
0
0
9
0
0
9
17
% V
% Trp:
0
9
25
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
9
9
0
0
0
17
0
9
0
9
0
9
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _